Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Tlhahlobo ea katleho ea Pharmacological

pharmacological-efficacy-analysis-sehlahisoa

Pharmacological efficacy analysis e bua ka tlhahlobo le tlhahlobo ea katleho ea lithethefatsi ho finyella liphello tsa bona tsa phekolo.Ke mohato oa bohlokoa ts'ebetsong ea nts'etsopele ea lithethefatsi le ho hlakisa melemo le mefokolo e ka bang teng ea motsoako oa meriana.

Ka tlhahlobo ea katleho ea meriana, bafuputsi ba ikemiselitse ho fumana hore na sethethefatsi se sebelisana hantle hakae le se amohelang sepheo sa sona kapa sistimi ea baeloji, e lebisang ho karabelo e lakatsehang ea 'mele.

MingCeler e ka fana ka mefuta e fapaneng e loketseng ea litoeba joalo ka motho le phetoho ea liphatsa tsa lefutso ho latela litlhoko tsa bareki, haholo-holo mefuta ea mafu e hlophisitsoeng ka liphatsa tsa lefutso e ka etsisang ts'ebetso ea nts'etsopele ea mafu a batho ka nepo, e ka sebelisoang ho lekola le ho sekaseka katleho ea lithethefatsi. ntlafatsa sekgahla sa katleho ya ntshetsopele ya dithethefatsi tse ntjha.

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Teko ea index ea mali ea biochemical

- In vitro e kokota kapa e fetelletseng ea liphatsa tsa lefutso tsa liphatsa tsa lefutso tsa lisele tse entsoeng ka liphatsa tsa lefutso

-In vivo e kokota kapa e fetelletseng ea liphatsa tsa lefutso ho mefuta ea litoeba

-Litlhahlobo tse sebetsang ka har'a vivo tse kenyelletsang kholo ea tumor, metastasis, joalo-joalo.·

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Boitšoaro ba Liphoofolo

· Teko ea bokhoni ba ho ithuta le ho hopola:

Maze ea metsi a Morris (memori ea ho ithuta ea sebaka, mohopolo oa ho sebetsa, mohopolo oa litšupiso, thuto e sothehileng, mohopolo o itšetlehileng ka hippocampal);Barnes maze (thuto ea sebaka le mohopolo);

· Tšabo e nang le maemo:

Mehopolo ea maikutlo, tšabo e amanang le hippocampal e itšetlehileng ka hippocampal, tšabo e sa itšetleheng ka hippocampal, mohopolo oa nako e telele, mohopolo oa nakoana, mohopolo o itšetlehileng ka amygdala, le karabelo ea tšabo.

·Teko ea Boitšoaro ba Matšoenyeho:

Elevated Cross Maze, Conditioned Fear Test, Absence Field Behaviour Test, Startle Response, le Social Interaction Behaviour.

· Liteko tsa boitšoaro bakeng sa khatello ea maikutlo:

Teko ea hypophagia e entsoeng ke tikoloho e ncha, teko ea mohatla o leketlileng, teko ea ho sesa e qobelloang, tlhahlobo ea boitšoaro ba ho ba sieo mosebetsing, teko ea boitšoaro ba likamano tsa sechaba, le ho hloka thuso.

· Liteko tsa boitšoaro tse amanang le bohloko:

Tekanyo ea bohloko ka poleiti e chesang, tekanyo ea bohloko ka ho tsukutleha ha mohatla (mocheso oa infrared le khatello ea maikutlo)

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Referense

[1]Othman MZ,Hassan Z, Che Has AT.Motsoako oa metsi oa Morris: sesebelisoa se feto-fetohang le se sebetsang bakeng sa ho lekola thuto ea sebaka le mohopolo.Exp Anim.2022 Aug 5;71(3):264-280.doi:10.1538/expanim.21-0120.Epub 2022 Mar 18. PMID: 35314563;PMCID: PMC9388345.

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